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PLANTS, ONE OF THOSE IS RESVERATROL, A SMALL PLANT |
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POLYPHENOL PRESENT IN RED WINE AND OTHERS!K.. |
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RESVERATROL IS PRESENT IN RED WINE - PINOT NOIRS |
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| 2004 |
STEPHEN HELFAND |
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RPD3 ENZYME IS DECREASED, LIFESPAN IS EXTENDED |
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IN YEAST, FLY, BY ABOUT 35, 40% |
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NORMAL FLY WITH CR/LE HAD LOWER RPD3 SIMILAR |
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TO THAT OF THE GENETICALLY MANIPULATED |
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RPD3 MUTANTS : NORMAL FOOD CONDITIONS |
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RPD3 MUTANTS : CR CONDITIONS - NO ADDED EFFECT |
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NORMAL FLIES : CR CONDITIONS |
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SIR2 IS INCREASED, LIFESPAN IS EXTENDED |
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RPD3 MUTANT WITH LE, HAD ELEVATED SIR2 |
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SIR2 MUTANT THAT PREVENTED IT FROM INCREASING |
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MAMMALS, AND THERE'S MORE SIR2-LIKE GENES |
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RESVERATROL CAN LE IN YEAST, ROUNDWORM AND FLY, |
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LE IS DEPENDENT ON SIR2'S ACTIVITY |
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CALORIC RESTRICTION |
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WITH OPTIMAL NUTRIENTS (CRON) |
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NUTRITIONAL REQUIREMENTS |
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